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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1974 2
1975 4
1976 6
1977 9
1978 3
1979 10
1980 3
1981 6
1982 5
1983 6
1984 5
1985 3
1986 9
1987 4
1988 5
1989 7
1990 11
1991 3
1992 5
1993 6
1994 3
1995 3
1996 2
1997 3
1998 3
1999 5
2000 14
2001 5
2002 3
2003 9
2004 2
2005 8
2006 8
2007 5
2008 7
2009 6
2010 8
2011 3
2012 8
2013 12
2014 4
2015 3
2016 5
2017 2
2018 1
2019 7
2020 4
2021 4
2022 10
2023 10
2024 3

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272 results

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Page 1
Analysis of the Complement System in the Clinical Immunology Laboratory.
Ling M, Murali M. Ling M, et al. Clin Lab Med. 2019 Dec;39(4):579-590. doi: 10.1016/j.cll.2019.07.006. Epub 2019 Oct 3. Clin Lab Med. 2019. PMID: 31668271 Review.
The complement system is a critical component of both the innate and adaptive immune systems that augments the function of antibodies and phagocytes. ...The importance of this system is highlighted by the disorders that arise when complement components or regulators …
The complement system is a critical component of both the innate and adaptive immune systems that augments the function of antibodies …
C3-dependent effector functions of complement.
Zarantonello A, Revel M, Grunenwald A, Roumenina LT. Zarantonello A, et al. Immunol Rev. 2023 Jan;313(1):120-138. doi: 10.1111/imr.13147. Epub 2022 Oct 22. Immunol Rev. 2023. PMID: 36271889 Free PMC article. Review.
To highlight the important role that C3 plays in human biological processes, we will give an overview of the diseases linked to C3 deficiency and to uncontrolled C3 activation. Next, we will present a structural description of C3 activation and …
To highlight the important role that C3 plays in human biological processes, we will give an overview of the diseases linked to C3 …
Complement.
Monach PA. Monach PA. Arthritis Rheumatol. 2024 Jan;76(1):1-8. doi: 10.1002/art.42671. Epub 2023 Oct 16. Arthritis Rheumatol. 2024. PMID: 37551641 Review.
The role of complement in human autoimmune, inflammatory, and infectious diseases is reviewed, focusing on clinical applicability. ...The review includes a discussion of complement deficiency states, consumption of complement by diseases characterized …
The role of complement in human autoimmune, inflammatory, and infectious diseases is reviewed, focusing on clinical applicability. .. …
Current understanding of IgA antibodies in the pathogenesis of IgA nephropathy.
Nihei Y, Suzuki H, Suzuki Y. Nihei Y, et al. Front Immunol. 2023 Apr 11;14:1165394. doi: 10.3389/fimmu.2023.1165394. eCollection 2023. Front Immunol. 2023. PMID: 37114051 Free PMC article. Review.
Meanwhile, IgA can induce IgA-mediated diseases, such as IgA nephropathy (IgAN) and IgA vasculitis. IgAN is characterized by the deposition of IgA and complement C3, often with IgG and/or IgM, in the glomerular mesangial region, followed by mesangial cell proliferat …
Meanwhile, IgA can induce IgA-mediated diseases, such as IgA nephropathy (IgAN) and IgA vasculitis. IgAN is characterized by the deposition …
Factor D.
Sekine H, Machida T, Fujita T. Sekine H, et al. Immunol Rev. 2023 Jan;313(1):15-24. doi: 10.1111/imr.13155. Epub 2022 Oct 31. Immunol Rev. 2023. PMID: 36316810 Review.
Complement factor D (FD) is a serine protease that plays an essential role in the activation of the alternative pathway (AP) by cleaving complement factor B (FB) and generating the C3 convertases C3(H(2) O)Bb and C3bBb. ...Here, we summarize the curren …
Complement factor D (FD) is a serine protease that plays an essential role in the activation of the alternative pathway (AP) by cleav …
The complement alternative pathway in paroxysmal nocturnal hemoglobinuria: From a pathogenic mechanism to a therapeutic target.
Risitano AM, Frieri C, Urciuoli E, Marano L. Risitano AM, et al. Immunol Rev. 2023 Jan;313(1):262-278. doi: 10.1111/imr.13137. Epub 2022 Sep 15. Immunol Rev. 2023. PMID: 36110036 Free PMC article. Review.
The lack of the complement regulators CD55 and CD59 on PNH erythrocytes accounts for the hallmark of PNH, which is the chronic, complement-mediated intravascular hemolysis. ...Nevertheless, the clinical use of an inhibitor of the terminal pathway highlighted the bro …
The lack of the complement regulators CD55 and CD59 on PNH erythrocytes accounts for the hallmark of PNH, which is the chronic, co …
Complement. First of two parts.
Walport MJ. Walport MJ. N Engl J Med. 2001 Apr 5;344(14):1058-66. doi: 10.1056/NEJM200104053441406. N Engl J Med. 2001. PMID: 11287977 Review. No abstract available.
Complement and the prothrombotic state.
Schmidt CQ, Schrezenmeier H, Kavanagh D. Schmidt CQ, et al. Blood. 2022 Mar 31;139(13):1954-1972. doi: 10.1182/blood.2020007206. Blood. 2022. PMID: 34415298 Free article. Review.
Next to PNH and aHUS, germline-encoded CD59 or CD55 deficiency (the latter causing the disease complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy), autoimmune hemolytic anemia, (catastrophic) antiphospholipid syndrome, and C3 g …
Next to PNH and aHUS, germline-encoded CD59 or CD55 deficiency (the latter causing the disease complement hyperactivation, ang …
Anti-complement-factor H-associated glomerulopathies.
Durey MA, Sinha A, Togarsimalemath SK, Bagga A. Durey MA, et al. Nat Rev Nephrol. 2016 Sep;12(9):563-78. doi: 10.1038/nrneph.2016.99. Epub 2016 Jul 25. Nat Rev Nephrol. 2016. PMID: 27452363 Review.
Autoantibodies against complement factor H (FH), the main plasma regulatory protein of the alternative pathway of the complement system, account for a considerable proportion of children with aHUS. ...Anti-FH autoantibodies are also detected in a small proportion of …
Autoantibodies against complement factor H (FH), the main plasma regulatory protein of the alternative pathway of the complement …
Dense deposit disease.
Smith RJ, Harris CL, Pickering MC. Smith RJ, et al. Mol Immunol. 2011 Aug;48(14):1604-10. doi: 10.1016/j.molimm.2011.04.005. Epub 2011 May 24. Mol Immunol. 2011. PMID: 21601923 Free PMC article. Review.
Studies of its pathophysiology have shown conclusively that it is caused by fluid-phase dysregulation of the alternative pathway of complement, however the role played by genetics and autoantibodies like C3 nephritic factors must be more thoroughly defined if we are …
Studies of its pathophysiology have shown conclusively that it is caused by fluid-phase dysregulation of the alternative pathway of compl …
272 results